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Modulation of Hormones DSIP has been linked to increased production of growth hormone (GH) during sleep and may suppress corticotropin (ACTH) and cortisol , aligning with its stress-relieving effects

Modulations of gene expression related to inflammatory signaling, angiogenic regulators, cell cycle control, and structural matrix proteins have been documented in preclinical and in vitro systems

Ruan et al., 2020

There is also variable contribution from T-helper type 1 (Th1) driven pathways, including interferon-gamma (IFN-) and interleukin 12 (IL-12), as well as T-helper type 17 (Th17) and T-helper type 22 (Th22) cells [25]

doi: 10.3390/ph18030334 129 ToledoBZhu ChenLPaniagua-SanchoMMarchalJAPernMGiovannettiE